
Research interests
Micro-organisms biophysicsPresentation
After 15 years spent in physiology laboratories studying cardiac energetic and mitochondria functioning, I decided to join Jean Perrin laboratory at UPMC. Using biomimetic systems such as lipid vesicles (GUVs), I study the properties of mitochondrial lipids, and in particular cardiolipids. I also try to understand how membrane invaginations mimicking "mitochondrial cristae" can be formed, and how these nanostructures and the resulting compartmentalization can influence the functioning of an enzyme such as the F1Fo ATPsynthase. For this research, I collaborate with various national and international laboratories. My research combines physicochemical and biophysical approaches, but also experiments on culture cells and on animal models having alterations in the organization of their mitochondrial membranes.
Publications
2024
⊞ | Role of cardiolipin in proton transmembrane flux and localization - Biophysical Journal (Dec. 2024) |
2021
⊞ | Isolation and Phospholipid Enrichment of Muscle Mitochondria and Mitoplasts - Bio Protoc (Oct. 2021) |
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Bibtex | doi:https://doi.org/10.21769/bioprotoc.4201 |
⊞ | Mitochondrial Cristae Architecture and Functions: Lessons from Minimal Model Systems - Membranes (Jun. 2021) |
⊞ | Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle - Science Advances (Jan. 2021) |
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Bibtex | doi:https://doi.org/10.1126/sciadv.abd6322 |
2020
⊞ | Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field - Phys. Rev. E (Aug. 2020) |
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Bibtex | doi:10.1103/PhysRevE.102.022401 |
2017
⊞ | Nonequilibrium fluctuations of lipid membranes by the rotating motor protein F1F0-ATP synthase - Proceedings of the National Academy of Sciences of the United States of America (Oct. 2017) |
URL | Full text PDF | Bibtex | doi:10.1073/pnas.1701207114 |
2014
⊞ | Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4 - Br. J. Pharmacol. (Dec. 2014) |
URL | Full text PDF | Bibtex | doi:10.1111/bph.12853 |
2013
⊞ | Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice - J. Physiol.-London (Dec. 2013) |
URL | Full text PDF | Bibtex | doi:10.1113/jphysiol.2013.263079 |
⊞ | Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell? - Front. Physiol. (May. 2013) |
URL | Full text PDF | Bibtex | doi:10.3389/fphys.2013.00102 |
2012
⊞ | Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload - Cardiovasc. Res. (Jun. 2012) |
URL | Full text PDF | Bibtex | doi:10.1093/cvr/cvs117 |
⊞ | Catecholamine-induced cardiac mitochondrial dysfunction and mPTP opening: protective effect of curcumin - Am. J. Physiol.-Heart Circul. Physiol. (Feb. 2012) |
URL | Full text PDF | Bibtex | doi:10.1152/ajpheart.00467.2011 |
2011
⊞ | Bioenergetics of the failing heart - Biochim. Biophys. Acta-Mol. Cell Res. (Jan. 2011) |
URL | Full text PDF | Bibtex | doi:10.1016/j.bbamcr.2010.09.006 |
2010
⊞ | Mitochondria as a source of mechanical signals in cardiomyocytes - Cardiovasc. Res. (Jul. 2010) |
URL | Full text PDF | Bibtex | doi:10.1093/cvr/cvq039 |
⊞ | Postnatal development of mouse heart: formation of energetic microdomains - J. Physiol.-London (Jul. 2010) |
URL | Full text PDF | Bibtex | doi:10.1113/jphysiol.2010.189670 |
2009
⊞ | Energetic state is a strong regulator of sarcoplasmic reticulum Ca2+ loss in cardiac muscle: different efficiencies of different energy sources - Cardiovasc. Res. (Jul. 2009) |
URL | Full text PDF | Bibtex | doi:10.1093/cvr/cvp125 |