The ability to detect motion, whether it results from movement of the observer or another object, is perhaps the most important task performed by the visual system. It is therefore not surprising that neurons responding to visual motion in direction-selective (DS) ways are found in the retinae of many different animal species. Intense research has provided significant insight into how retinal circuits establish DS responses from the non-selective input provided by the photoreceptors. What is less well understood is the fate of DS signals after they leave the retina. How do the axons of different DS retinal ganglion cell (RGC) subtypes target different regions of the brain and how is the information carried by DS RGCs used by postsynaptic circuits? The talk will focus on the experimental approaches used to address these questions using the larval zebrafish as a model system, and recent progress we have made in understanding how retinal direction-selectivity is delivered to, and transformed by circuits within the optic tectum.