Statistical estimation of a growth-fragmentation model observed on a genealogical tree

M. Doumic , M. Hoffmann , N. Krell , L. Robert

Bernoulli, 21, 3, 1760-1799
Published 18 Jan. 2015
DOI: 10.3150/14-BEJ623


We raise the issue of estimating the division rate for a growing and dividing population modelled by a piecewise deterministic Markov branching tree. Such models have broad applications, ranging from TCP/IP window size protocol to bacterial growth. Here, the individ-uals split into two offsprings at a division rate B(x) that depends on their size x, whereas their size grow exponentially in time, at a rate that exhibits variability. The mean empirical measure of the model satisfies a growth-fragmentation type equation, and we bridge the determinis-tic and probabilistic viewpoints. We then construct a nonparametric estimator of the division rate B(x) based on the observation of the pop-ulation over different sampling schemes of size n on the genealogical tree. Our estimator nearly achieves the rate n ?s/(2s+1) in squared-loss error asymptotically, generalizing and improving on the rate n ?s/(2s+3) obtained in [13, 15] through indirect observation schemes. Our method is consistently tested numerically and implemented on Escherichia coli data, which demonstrates its major interest for practical applications.

Cette publication est associée à :

Biophysique des micro-organismes