In this seminar, I will present the past and current work of my team at IBPS, aiming at constructing perfusable microvessels to develop physiologically-relevant tissue microenvironments on chip. First, I will present how a Marangoni-like Matrigel sessile droplet helped guide the self-organization of a fully lumenized liver-specific microvessel. Then I will present some progress made on capillaries on chip devices developed in our lab to vascularize complex 3D tissues and cancer spheroids, to study pathological mechanisms in vitro.