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Statistical mechanics for the analysis of immunogenic motives in SARS-COv2 sequences and beyond
Par Simona Cocco (LPENS Paris)
Le 11 Janvier 2022 à 11h00 - Salle de séminaires 5ème étage, Tour 32-33

Résumé

When a virus enters a new host, it can present pathogen-associated molecular patterns (PAMPs) that are rarely seen in circulating strains that have adapted to that host’s immune environment over evolutionary timescales. I will present some recent works on the prediction of evolution of SARS-COv2 sequences to adapt to the human host through synonymous mutations and escape   the innate immune recognition. If time permits I will also present a different, but not unrelated, work on the  study  of optimal   vaccination protocol in  antigen dosage.

Related bibliography :

-The heterogeneous landscape and early evolution of pathogen-associated CpG dinucleotides in SARS-CoV-2 
A. Di Gioacchino, P. Sulc, A.V. Komarova, B.D. Greenbaum, R. Monasson, S. Cocco 
Molecular Biology and Evolution 38, 2428-2445 (2021) 

-Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers 
M. Molari, K. Eyer, J. Baudry, S. Cocco, R. Monasson 
eLife 2020 9:e55678 (2020)